Skip to main content

Image Gallery Heinrich Wieland Prize 2022

https://boehringer-ingelheim-stiftung.de

2022 Heinrich Wieland Prize: Image Gallery

Xiaowei Zhuang of Harvard University in Cambridge, USA, will receive the 2022 Heinrich Wieland Prize of the Boehringer Ingelheim Foundation worth 100,000 euros on 6 October for making seminal discoveries in cell and neurobiology with the ingenious imaging technologies she developed. Thanks to her work we can observe how structures about 100 atoms wide do their work in human cells and get clear snapshots of the activity of 10,000 genes within one cell at the same time. Over the past 16 years, Professor Zhuang along with scientists worldwide have gained valuable insights into complex biological processes using STORM, her super-resolution method, and MERFISH, her genome-scale imaging method.

Below, you will find a selection of the stunning images she has generated with STORM and MERFISH.

All images copyright Xiaowei Zhuang, HHMI, Harvard University

Click on an image to start image gallery.

Comparison of conventional and 3D STORM image of mitochondria in a cell. Left: Conventional image of the left 1/3 of the cell. Middle: 3D STORM image of the middle 1/3 of the cell. The z-dimension information is color-coded. Right: xy cross-section of the 3D STORM image of the right 1/3 of the cell.
3D STORM image of actin in a cell. The z-dimension information is color-coded.
Comparison of conventional (left) and STORM (right) image of microtubules (green) and clathrin-coated pits (red) in a cell.
STORM imaging revealed a novel membrane-associated periodic skeleton structure in neurons, which is comprised of actin, spectrin and other molecules. Shown here is the comparison of conventional (upper) and 3D STORM (lower) images of actin in the axons of neurons. The z-dimension information is color-coded.
MERFISH image of 10,050 genes in individual cells. RNA molecules from different genes are shown in different colors.
Cell atlas of a region in the mouse brain (the preoptic region of the hypothalamus) generated by MERFISH. Different types of cells are shown in different colors.
Cell atlas of a region in the mouse brain (the preoptic region of the hypothalamus) generated by MERFISH. Different types of cells are shown in different colors.
Cell atlas of a region in the human brain (temporal gyrus in the cortex) generated by MERFISH. Different types of cells are shown in different colors.

Back to main page

Click here to return to main page.