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News from the Boehringer Ingelheim Foundation.

Professor Pascale Cossart of the Institut Pasteur in Paris will be honoured with the 2018 Heinrich Wieland Prize for her fundamental contributions to Molecular Infection Biology. Cossart's innovative research has unravelled how pathogenic bacteria, in particular food-borne Listeria, enter human cells, use the host cells' own mechanisms to do so, and trick and evade the immune system. Her discoveries have paved the way toward new therapies for bacterial infections, which kill several million people worldwide each year. The 100,000-euro prize awarded by the non-profit Boehringer Ingelheim Foundation will be presented during a scientific symposium in Munich, Germany, on 22 November 2018.

Link to the full press release

Link to an image of mammalian cell infected by Listeria: Listeria (red) signal infected cells to form comet-like tails from actin (green) that push them through their host cells (blue=cell nuclei). © Pascale Cossart

 

 

From left: Dr Claudia Walther, Dr Frank Bicker, Otto Boehringer, Dr Thor Voigt, Dr Swenja Kröller-Schön, Prof. Dr Stefan Müller-Stach, Prof. Dr Norbert Pfeiffer, Prof. Dr Ulrich Förstermann, Marion Hahn, Prof. Dr Heinz Schmidberger (Photo: Jürgen Arlt)

Two biologists of the University Medical Center Mainz honoured

The Boehringer Ingelheim Foundation has awarded the 2018 Boehringer Ingelheim Prize to Dr Frank Bicker and Dr Swenja Kröller-Schön, both biologists, in a festive act. The prize – endowed with a total of 30,000 euros – is shared equally between the two junior scientists from the University Medical Center Mainz.

Dr Swenja Kröller-Schön unravelled the molecular mechanism through which aircraft noise can harm blood vessels and can thus lead to cardiovascular disease. Dr Frank Bicker provided evidence for an essential role of the protein EGFL7 in the production of new nerve cells in the adult brain. His discoveries have direct implications for lifelong learning and may help in developing new therapeutic approaches in regenerative medicine.

To the press release (in German).

The non-profit Boehringer Ingelheim Foundation and the State of Rhineland-Palatinate will fund the Institute of Molecular Biology (IMB) at the University of Mainz with a further 106 million euros from 2020 to 2027. The Foundation will contribute about 54 million euros and the state 52 million euros. This was announced in Mainz today by Malu Dreyer, minister-president of Rhineland-Palatinate, and Christoph Boehringer, chairman of the executive board of the Boehringer Ingelheim Foundation.

Translation of the press release

Link to the new contractual agreement regarding the funding of the IMB (only available in German)

Information on the IMB

Link zum Jahresbericht des IMB

Link to the 2012-contractual agreement regarding the funding of the IMB (only available in German)

The 2017 Heinrich Wieland Prize has been awarded to Prof. Alexander Varshavsky (c) A. Griesch
The 2017 Heinrich Wieland Prize has been awarded to Prof. Alexander Varshavsky (c) A. Griesch

Professor Alexander Varshavsky from the California Institute of Technology, USA, has received the 2017 Heinrich Wieland Prize for discovering the biology of the ubiquitin system. Dr Varshavsky showed that the ubiquitin system is a master regulator that precisely tunes the levels of proteins in cells, thereby controlling a strikingly wide range of their processes, including division, protein synthesis, and stress responses. The 100,000-euro prize awarded by the non-profit Boehringer Ingelheim Foundation was presented during a scientific symposium in Munich, Germany, on 19 October 2017.

Link to the full press release 

Link to an image of the three-dimensional structure of the protein ubiquitin. Caption: In red, areas where the ubiquitin can attach to itself to form chains, blue is the N-end, yellow the C-end of the amino acid chain. Copyright: Paul Riviere, CC_BY-SA 3.0

Click on the image to see the film "Seeing is understanding" with a 3D animation of this image as well as further snapshots of life, which led to important discoveries, and a first impression of the planned Imaging Technology Centre. Image: J Cell Sci 201
Click on the image to see the film "Seeing is understanding" with a 3D animation of this image as well as further snapshots of life, which led to important discoveries, and a first impression of the planned Imaging Technology Centre. Image: J Cell Sci 2016 129:444-456

In 2018, the construction of a unique centre for unifying the latest technologies in optical and electron microscopy will begin at the European Molecular Biology Laboratory (EMBL) in Heidelberg. The Boehringer Ingelheim Foundation will donate 5 million euros over a period of 15 years primarily toward the training of guest scientists from around the world in the use of the highly complex microscopes, and toward support for their research projects with them.

Particularly when applied in combination, new imaging technologies promise to enable unprecedented insights and findings in life sciences research. Yet, nowhere in the world is there currently a centre dedicated to giving researchers access to the combination of the latest optical and electron microscopy technologies, to training scientists to work with the complex technologies, and to refining these technologies. In fact, even the access to each of the very expensive and complex technologies by itself is currently limited to only a few sites.

In 2018, construction of the Imaging Technology Centre will begin in Heidelberg at the European Molecular Biology Laboratory (EMBL), one of the world’s foremost basic research centres. It will be the first centre to provide researchers from all over the globe access to these technologies in combination.

The building and the equipment of the new centre will be financed by the German federal government, the state government of Baden-Wuerttemberg, and industry. The ground-breaking ceremony will take place in the summer of 2018.

To the press release of the EMBL.

 

 

From left: Prof. Dr Ulrich Förstermann, PD Dr Jörg Fahrer, Christoph Boehringer, PD Dr Katharina Ponto, Dr Thor Voigt, Prof. Dr Hansjörg Schild. Photo: Jürgen Arlt

Toxicologist Dr Jörg Fahrer found out, how cells of the colon react to certain cancer-causing agents that are produced, for example, while roasting meat and how the cell protects itself against damage to its DNA and damage-induced cell death. His results help to understand better how cancer of the colon develops.

Opthomalogist Dr Katharina Ponto analyzed data from a large health study and thus delivered the first sound and informative numbers about retinal damage in very early-stage diabetes patients. Her data suggest that targeted screening programmes could help to prevent retinal damage due to diabetes.

To the press release (in German).

From left: Dr E. Frank, O. Boehringer, Prof. B. Simon, Dr T. Voigt, Dr. A Baranowski, Dr. G Gasteiger, Prof. U. Förstermann, Dr C. Walther, Prof. M. Beutel. Photo: T. Böhm

Dr Andreas Baranowski discovered that prosthesis made of titanium and coated with "bone sialoprotein", an innate protein of the bone, activate bone-specific genes. This could in the future result in a better anchoring of the prosthesis in the bone, and thus a more durable and stable fit.

Dr Georg Gasteiger proved that certain cells of the innate immune system, the so-called ILCs, are local defence cells adapted to their respective tissues. This finding is a significant step in understanding immune system function.

To the press release (in German).

The chemist Peter Schultz has been honoured with the 2016 Heinrich Wieland Prize for his fundamental contributions to the biologically inspired synthesis of new molecules and, in particular, for the expansion of the genetic code. Schultz, professor at The Scripps Research Institute in California, combines nature’s own methods with principles from the chemistry laboratory to create molecules with new functions to use as drugs, study life, or synthesize new materials. His findings have already led to the development of new drugs – some approved, others in the clinical trial stage – against degenerative diseases, cancer, autoimmune, and neglected diseases. The Boehringer Ingelheim Foundation has presented the international 100,000-euro award to him during a scientific symposium on synthetic biology on 13 October 2016 in Munich.

To the press release

Translation of the German-language joint declaration issued by the Boehringer Ingelheim Foundation and the University of Mainz on 16 September 2016 regarding their partnership:

A common goal: Best conditions for world-leading scientists and the freedom for excellent research

Mainz, 16 September 2016: The Boehringer Ingelheim Foundation is devoted to promoting excellence in basic research in the fields of medicine, biology, chemistry, and pharmacy, and in this endeavour puts special emphasis on nurturing  junior scientists. Since its establishment in 1977, the Boehringer Ingelheim Foundation has concentrated a considerable portion of its funding in the Johannes Gutenberg University of Mainz, due to commitment to its home region.

Translation of the German-language joint declaration

Translation of the German-language press release issued by the Boehringer Ingelheim Foundation on 27 May 2016 regarding the Mainz administrative court’s grounds for judgement with respect to the contractual arrangements between the University of Mainz and the Boehringer Ingelheim Foundation:

Boehringer Ingelheim Foundation welcomes clarifying court ruling

Mainz, 27 May 2016: On Tuesday, 24 May 2016, the administrative court of Mainz published its grounds for judgement concerning Prof. Dr. Thomas Leif versus the University of Mainz. Two weeks earlier, on 11 May 2016, the court had agreed with the position of the University and the Foundation, and denied a general right of access to contracts regarding third-party funding, under the former Landesinformationsfreiheitsgesetz (State Freedom of Information Act, in effect until 31 Dec 2015), as well as under the new Landestransparenzgesetz (State Transparency Act, in effect since 1 Jan 2016).

Translation of the German-language press release